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Buy Quality 2-Aminopurine 452-06-2 In Stock with Immediately Delivery
- Molecular Formula: C5H5N5
- Molecular Weight: 135.128
- Appearance/Colour: White to light yellow crystal powder
- Vapor Pressure: 0.00172mmHg at 25°C
- Melting Point: 280-282 °C(lit.)
- Refractive Index: 1.954
- Boiling Point: 616.3 °C at 760 mmHg
- PKA: 8.02±0.20(Predicted)
- Flash Point: 362.9 °C
- PSA： 80.48000
- Density: 1.612 g/cm3
- LogP: 0.51630
2-Aminopurine(Cas 452-06-2) Usage
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Biochem/physiol Actions |
2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR). |
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Safety Profile |
Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx. |
|
Definition |
ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position. |
InChI:InChI=1/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-3H,(H2,6,8,9,10)
452-06-2 Relevant articles
Structure of amipurimycin, a nucleoside antibiotic having a novel branched sugar moiety
Goto,Toya,Ohgi,Kondo
, p. 1271 - 1274 (1982)
-
Meteorites as catalysts for prebiotic chemistry
Saladino, Raffaele,Botta, Giorgia,Delfino, Michela,Di Mauro, Ernesto
, p. 16916 - 16922 (2014/01/06)
From outer space: Twelve meteorite speci...
Synthesis and degradation of nucleic acid components by formamide and iron sulfur minerals
Saladino, Raffaele,Neri, Veronica,Crestini, Claudia,Costanzo, Giovanna,Graciotti, Michele,Di Mauro, Ernesto
experimental part, p. 15512 - 15518 (2009/03/12)
We describe the one-pot synthesis of a l...
Nucleoside analogue phosphates for topical use
-
, (2008/06/13)
Compositions for topical use in herpes v...
4'-substituted nucleosides
-
, (2008/06/13)
Nucleosides compounds of Formula I: STR1...
452-06-2 Process route
-
-
77287-34-4,77287-35-5,60100-09-6
formamide
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-
557-01-7
Pyrimidin-2(1H)-one
-
-
151-51-9,25215-75-2
carbodiimide
-
-
108-53-2,145358-63-0,674-97-5,176772-97-7
isocytosine
-
-
120-73-0,149297-77-8,51953-03-8
purine
-
-
452-06-2,849611-62-7,191236-69-8
7H-purin-2-amine
-
-
66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine
-
-
57-13-6
urea
Conditions
| Conditions | Yield |
|---|---|
|
With
iron sulfide;
at 160 ℃;
for 48h;
|
-
-
10310-21-1
2-Amino-6-chloropurin
-
-
452-06-2
9H-purin-2-amine
Conditions
| Conditions | Yield |
|---|---|
|
In
hydrogenchloride;
at 50 ℃;
electrolysis, -0.75V, initial current 50-60 mA;
|
85%
|
|
palladium on charcoal;
In
sodium hydroxide; water;
|
452-06-2 Upstream products
-
4394-85-8
4-morpholinecarboxaldehyde
-
3546-50-7
pyrimidine-2,4,5-triamine
-
77287-34-4
formamide
-
33512-51-5
2-(methylthio)-9H-purine
452-06-2 Downstream products
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2308-57-8
1,3-dihydro-2H-purin-2-one
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1598-61-4
2-fluoro-7(9)H -purine
-
226247-80-9
2-amino-9-benzyl-9H-purine
-
143883-60-7
methyl 3-(2-amino-9H-purin-9-yl)propionate
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